‘Certainly, that is certainly about suitable. I seek out a Actual physical knowledge of Organic methods in a very bottom-up way. I believe you could potentially distinguish three traces of investigate in my group at this time. The initial problems chromosome construction: How will you get a metre-extended DNA polymer folded and organised in this type of microscopic mobile? We have produced visualisation approaches that allow for us to study how, by way of example, SMC proteins loop DNA (online video on Youtube) in order to Develop up chromosomes.

Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transport of macromolecules

For a individual, I possess the biblical assignment to check out and use all the things in development for the good thing about my neighbour. I do not expertise any conflict involving religion and science. On the contrary, my faith stimulates me to accomplish science, being open up-minded in the world.’

Unfortunately, For several years right after Iijima’s report, the creation of thoroughly clean nanotubes was cumbersome. In 1996, having said that, the group of Richard Smalley at Rice College managed to provide solitary-walled carbon nanotubes at high produce. Soon immediately after, I contacted Smalley, and we decided to be a part of forces to evaluate the transport through a one carbon nanotube.

We build stage-of-treatment diagnostics exam of neglected tropical disorders in resource-limited configurations, based upon Crspr/Cas9 detecting of pathogen’s DNA in entire body fluids.

Direct immobilization of indigenous yeast iso-1 cytochrome c cees dekker on bare gold: rapidly electron relay to redox enzymes and zeptomole protein-film voltammetry

Considering that 2000 he moved to single-molecule biophysics and nanobiology, with study from DNA supercoiling studies of nucleosomes and DNA maintenance proteins to DNA translocation by nanopores. Not long ago his analysis has focused on studying mobile division with microorganisms on chip, although his ultimate desire is while in the path of realizing artificial cells.

Atomic force microscopy exhibits that vaccinia topoisomerase IB generates filaments on DNA in a very cooperative fashion

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Resolving the stage measurement in condensin-pushed DNA loop extrusion identifies ATP binding as the action-creating approach

An built-in microfluidic System for quantifying drug permeation throughout biomimetic vesicle membranes

Lots of new phenomena have been uncovered, and he and his study team set up a number one placement in this subject of analysis. Dekker and his investigate group found out new physics of nanotubes and also explored the feasibility of molecular electronics. In 1998, they were the 1st to construct a transistor based upon just one nanotube molecule.

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Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij fulfilled enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond clever style in 2005. (nl)